World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Evolution of Sex-specific Traits Through Changes in Hoxdependent Doublesex Expression, Volume 9

By Hawley, R. Scott

Click here to view

Book Id: WPLBN0003952189
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Evolution of Sex-specific Traits Through Changes in Hoxdependent Doublesex Expression, Volume 9  
Author: Hawley, R. Scott
Volume: Volume 9
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


APA MLA Chicago

Hawley, R. S. (n.d.). Plos Biology : Evolution of Sex-specific Traits Through Changes in Hoxdependent Doublesex Expression, Volume 9. Retrieved from

Description : Almost every animal lineage is characterized by unique sex-specific traits, implying that such traits are gained and lost frequently in evolution. However, the genetic mechanisms responsible for these changes are not understood. In Drosophila, the activity of the sex determination pathway is restricted to sexually dimorphic tissues, suggesting that spatial regulation of this pathway may contribute to the evolution of sex-specific traits. We examine the regulation and function of doublesex (dsx), the main transcriptional effector of the sex determination pathway, in the development and evolution of Drosophila sex combs. Sex combs are a recent evolutionary innovation and show dramatic diversity in the relatively few Drosophila species that have them. We show that dsx expression in the presumptive sex comb region is activated by the HOX gene Sex combs reduced (Scr), and that the male isoform of dsx up-regulates Scr so that both genes become expressed at high levels in this region in males but not in females. Precise spatial regulation of dsx is essential for defining sex comb position and morphology. Comparative analysis of Scr and dsx expression reveals a tight correlation between sex comb morphology and the expression patterns of both genes. In species that primitively lack sex combs, no dsx expression is observed in the homologous region, suggesting that the origin and diversification of this structure were linked to the gain of a new dsx expression domain. Two other, distantly related fly lineages that independently evolved novel male-specific structures show evolutionary gains of dsx expression in the corresponding tissues, where dsx may also be controlled by Scr. These findings suggest that changes in the spatial regulation of sex-determining genes are a key mechanism that enables the evolution of new sex-specific traits, contributing to some of the most dramatic examples of phenotypic diversification in nature.


Click To View

Additional Books

  • Plos Biology : Tscot+ Thymic Epithelial ... (by )
  • Plos Biology : Emerin Caps the Pointed E... (by )
  • Plos Biology : Il-26 Kick-starts Rheumat... (by )
  • Plos Biology : a New Approach for Using ... (by )
  • Plos Biology : Systematic Dissection of ... (by )
  • Plos Biology : Comment on “recent Origin... (by )
  • Plos Biology : Vocal Experimentation in ... (by )
  • Plos Biology : Resurrecting an Ancient E... (by )
  • Plos Biology : Plos Biology—we’re Open, ... (by )
  • Plos Biology : Receptive Fields in Prima... (by )
  • Plos Biology : Molecules That Cause or P... (by )
  • Plos Biology : Structural Basis for the ... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library on the Kindle are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.