World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Immunomodulation by Bifidobacterium Infantis 35624 in the Murine Lamina Propria Requires Retinoic Acid- Dependent and Independent Mechanisms, Volume 8

By Bereswill, Stefan

Click here to view

Book Id: WPLBN0003950162
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Immunomodulation by Bifidobacterium Infantis 35624 in the Murine Lamina Propria Requires Retinoic Acid- Dependent and Independent Mechanisms, Volume 8  
Author: Bereswill, Stefan
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Bereswill, S. (n.d.). Plos One : Immunomodulation by Bifidobacterium Infantis 35624 in the Murine Lamina Propria Requires Retinoic Acid- Dependent and Independent Mechanisms, Volume 8. Retrieved from http://kindle.worldlibrary.net/


Description
Description : Appropriate dendritic cell processing of the microbiota promotes intestinal homeostasis and protects against aberrant inflammatory responses. Mucosal CD103+ dendritic cells are able to produce retinoic acid from retinal, however their role in vivo and how they are influenced by specific microbial species has been poorly described. Bifidobacterium infantis 35624 (B. infantis) feeding to mice resulted in increased numbers of CD103+retinaldehyde dehydrogenase (RALDH)+ dendritic cells within the lamina propria (LP). Foxp3+ lymphocytes were also increased in the LP, while TH1 and TH17 subsets were decreased. 3,7-dimethyl-2,6-octadienal (citral) treatment of mice blocked the increase in CD103+RALDH+ dendritic cells and the decrease in TH1 and TH17 lymphocytes, but not the increase in Foxp3+ lymphocytes. B. infantis reduced the severity of DSS-induced colitis, associated with decreased TH1 and TH17 cells within the LP. Citral treatment confirmed that these effects were RALDH mediated. RALDH+ dendritic cells decreased within the LP of control inflamed animals, while RALDH+ dendritic cells numbers were maintained in the LP of B. infantis-fed mice. Thus, CD103+RALDH+ LP dendritic cells are important cellular targets for microbiota-associated effects on mucosal immunoregulation.

 

Click To View

Additional Books


  • Plos One : Clinical Utility of Insulin-l... (by )
  • Plos One : Trypanosoma Cruzi Coaxes Card... (by )
  • Plos One : the Speed of Range Shifts in ... (by )
  • Plos One : Medication Adherence in the G... (by )
  • Plos One : the Lethal Toxin from Austral... (by )
  • Plos One : Cardiac Peroxisome Proliferat... (by )
  • Plos One : Genomic Organization, Phyloge... (by )
  • Plos One : a Simple and Efficient Method... (by )
  • Plos One : Mitigation of Oxidative Damag... (by )
  • Plos One : Detection of Methylated Sept9... (by )
  • Plos One : Yy1-binding Sites Provide Cen... (by )
  • Plos One : Association of the European L... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library on the Kindle are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.