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Plos One : Genome-wide Association Identifies Multiple Genomic Regions Associated with Susceptibility to and Control of Ovine Lentivirus, Volume 7

By Lin, Baochuan

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Book Id: WPLBN0003938129
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Genome-wide Association Identifies Multiple Genomic Regions Associated with Susceptibility to and Control of Ovine Lentivirus, Volume 7  
Author: Lin, Baochuan
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
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Publisher: Plos

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Lin, B. (n.d.). Plos One : Genome-wide Association Identifies Multiple Genomic Regions Associated with Susceptibility to and Control of Ovine Lentivirus, Volume 7. Retrieved from http://kindle.worldlibrary.net/


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Description : These associations provide targets for mutation discovery in sheep susceptibility to OvLV. Aside from TMEM154, these genes have not been associated previously with lentiviral infection in any species, to our knowledge. Further, data from other species suggest functional hypotheses for future testing of these genes in OvLV and other lentiviral infections. Specifically, SYTL3 binds and may regulate RAB27A, which is required for enveloped virus assembly of human cytomegalovirus. Zinc finger transcription factors have been associated with positive selection for repression of retroviral replication. DLGAP1 binds and may regulate DLG1, a known regulator of HIV infectivity.

 

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