World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Dynamics of the Ethanolamine Glycerophospholipid Remodeling Network, Volume 7

By Xu, Ying

Click here to view

Book Id: WPLBN0003936618
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Dynamics of the Ethanolamine Glycerophospholipid Remodeling Network, Volume 7  
Author: Xu, Ying
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Xu, Y. (n.d.). Plos One : Dynamics of the Ethanolamine Glycerophospholipid Remodeling Network, Volume 7. Retrieved from http://kindle.worldlibrary.net/


Description
Description : Acyl chain remodeling in lipids is a critical biochemical process that plays a central role in disease. However, remodeling remains poorly understood, despite massive increases in lipidomic data. In this work, we determine the dynamic network of ethanolamine glycerophospholipid (PE) remodeling, using data from pulse-chase experiments and a novel bioinformatic network inference approach. The model uses a set of ordinary differential equations based on the assumptions that (1) sn1 and sn2 acyl positions are independently remodeled: (2) remodeling reaction rates are constant over time: and (3) acyl donor concentrations are constant. We use a novel fast and accurate two-step algorithm to automatically infer model parameters and their values. This is the first such method applicable to dynamic phospholipid lipidomic data. Our inference procedure closely fits experimental measurements and shows strong cross-validation across six independent experiments with distinct deuterium-labeled PE precursors, demonstrating the validity of our assumptions. In constrast, fits of randomized data or fits using random model parameters are worse. A key outcome is that we are able to robustly distinguish deacylation and reacylation kinetics of individual acyl chain types at the sn1 and sn2 positions, explaining the established prevalence of saturated and unsaturated chains in the respective positions. The present study thus demonstrates that dynamic acyl chain remodeling processes can be reliably determined from dynamic lipidomic data.

 

Click To View

Additional Books


  • Plos One : Cardiomyocyte Specific Deleti... (by )
  • Plos One : Analysis of Fgf-dependent and... (by )
  • Plos One : Outpatient Therapeutic Feedin... (by )
  • Plos One : Correlations Between Income I... (by )
  • Plos One : Melanoregulin, Product of the... (by )
  • Plos One : Scaffold-based Pan-agonist De... (by )
  • Plos One : Analysis of Metagenomic Data ... (by )
  • Plos One : the Steppengrille Gryllus Spe... (by )
  • Plos One : Protein Secretion is Required... (by )
  • Plos One : Insights Into Factorless Tran... (by )
  • Plos One : Diminished Vision in Healthy ... (by )
  • Plos One : Rising Diabetes Prevalence Am... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library on the Kindle are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.