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Plos One : Corneal Wound Healing is Compromised by Immunoproteasome Deficiency, Volume 7

By Mohan, Rajiv, R.

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Book Id: WPLBN0003935611
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Corneal Wound Healing is Compromised by Immunoproteasome Deficiency, Volume 7  
Author: Mohan, Rajiv, R.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Publication Date:
Publisher: Plos


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Mohan, R. R. (n.d.). Plos One : Corneal Wound Healing is Compromised by Immunoproteasome Deficiency, Volume 7. Retrieved from

Description : Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury. The current study investigates how the absence of immunoproteasome affects the corneal epithelium under normal and stressed conditions by comparing corneas from wildtype (WT) mice and those deficient in two immunoproteasome catalytic subunits (lmp72/2/mecl-12/2, L7M1). Immunoproteasome expression was confirmed in WT epithelial cells and in cells of the immune system that were present in the cornea. More apoptotic cells were found in both corneal explant cultures and uninjured corneas of L7M1 compared to WT mice. Following mechanical debridement, L7M1 corneas displayed delayed wound healing, including delayed re-epithelialization and re-establishment of the epithelial barrier, as well as altered inflammatory cytokine production compared to WT mice. These results suggest that immunoproteasome plays an important role in corneal homeostasis and wound healing.


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