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In Vivo Metabolism of 3, 2 '-Dimethyl-4- Aminobiphenyl (Dmab) Bearing on Its Organotropism in the Syrian Golden Hamster and the F344 Rat.

By Nussbaum, Miriam

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Book Id: WPLBN0000167012
Format Type: PDF eBook
File Size: 0.1 MB
Reproduction Date: 2005

Title: In Vivo Metabolism of 3, 2 '-Dimethyl-4- Aminobiphenyl (Dmab) Bearing on Its Organotropism in the Syrian Golden Hamster and the F344 Rat.  
Author: Nussbaum, Miriam
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Nussbaum, M. (n.d.). In Vivo Metabolism of 3, 2 '-Dimethyl-4- Aminobiphenyl (Dmab) Bearing on Its Organotropism in the Syrian Golden Hamster and the F344 Rat.. Retrieved from http://kindle.worldlibrary.net/


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Government Reference Publication

Excerpt
Excerpt: During comparative carcinogenicity studies with various derivatives of 4-aminobiphenyl. Walpole et al. (1-3) observed that the Introduction: of a methyl group ortho to the amine function (Bmethyl-bamino biphenyl) resulted in increased carcinogenicity to wards the intestinal tract of rats. On the other hand, methyl substitution meta to the amine (2- methyl-4-aminobiphenyl) decreased the carcinogenicity and changed the organotropism, with the appearance of liver rather than intestinal tumors. The Introduction: of a second methyl group at the 2 position to give 3,2-dimethyl4-aminobipheny(lD MAB), enhanced the carcinogenicity toward the intestinal tract even further; moreover significant carcinoge nicity appeared toward the ear duct, the salivary gland and other organs. Interestingly a methoxy group ortho to the amine produced a carcinogen with organotropism toward the urinary bladder. These relationships are summarized in Table 1. To.

 

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